Related Experiment Video
Updated: Jul 4, 2026

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
Published on: November 9, 2017
Childhood multifocal acquired demyelinating sensory and motor neuropathy
Hiroyuki Wakamoto1, Aya Chisaka, Naozou Inoue
1Department of Pediatrics, Ehime Prefecture Central Hospital, Kasuga-cho 83, Matsuyama-shi, Ehime Prefecture 798-0024, Japan. c-hwakamoto@eph.pref.ehime.jp
Abstract:
We report the first pediatric cases of multifocal acquired demyelinating sensory and motor neuropathy with electrophysiologic evidence of proximal conduction abnormalities but no definite conduction block. Intravenous immunoglobulin caused clinical improvement followed by long-term remission without maintenance therapy; one patient has exhibited a monophasic course and the other has had a single relapse during the last 5 years. These cases suggest that there may be a long-term sustained beneficial effect of intravenous immunoglobulin therapy for children with this neuropathy.
Related Concept Videos
Multiple Sclerosis l: Introduction
Poliomyelitis
Diabetic Neuropathy
Botulism
Myasthenia Gravis ll: Pathophysiology
Diphtheria

