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HER3 expression in cutaneous tumors.

Eva Wimmer¹, Gertraud Kraehn-Senftleben, Wolfgang J Issing

¹Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig-Maximilians-University, Munich, Germany. ehilgert@gmx.net

Anticancer Research

|May 30, 2008

Summary

Human epidermal growth factor receptor 3 (HER3) is expressed in various skin cancers. HER3 expression correlates with tumor thickness and suggests increased malignant potential in cutaneous lesions.

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Area of Science:

Oncology
Dermatology
Molecular Biology

Background:

The role of receptor tyrosine kinase HER3 in skin malignancies is not fully understood.
HER3 expression patterns in normal skin and various cutaneous tumors require detailed investigation.

Purpose of the Study:

To compare HER3 expression characteristics in normal skin and diverse cutaneous malignancies.
To investigate the association between HER3 expression and tumor thickness in skin cancers.

Main Methods:

HER3 expression was analyzed using RT-PCR and immunohistochemistry.
Tissue specimens included nevi, basal cell carcinoma, squamous cell carcinoma, malignant melanoma (primary and metastatic), and normal skin.
HER3 expression was graded as weak, moderate, or strong.

Main Results:

HER3 expression was detected in 63% of basal cell carcinomas and 80% of squamous cell carcinomas.
HER3 was found in 35% of nodular melanomas and 47% of superficial spreading melanomas.
Increased HER3 expression was associated with higher tumor thickness and 85% of melanoma metastases were HER3-positive.

Conclusions:

HER3 expression is linked to hyperproliferative tumor stages in cutaneous lesions.
HER3 expression may indicate an elevated malignant potential in skin cancers.
HER3 represents a potential therapeutic target in advanced cutaneous malignancies.

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