Related Experiment Video
Updated: Jul 4, 2026

Rapid Quantification of Oxidized and Reduced Forms of Glutathione Using Ortho -phthalaldehyde in Cultured Mammalian Cells In Vitro
Published on: June 28, 2024
Association between serum gamma-glutamyltransferase and oxidative stress related factors
Tomoko Takigawa1, Yuri Hibino, Shingo Kimura
1Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Background/Aims:
To investigate the main factors correlated with the serum gamma-glutamyltransferase activity.
Methodology:
We measured serum gamma-glutamyltransferase activity in 248 healthy Japanese people and determined its correlations with serum antioxidants, other plasma or serum factors, urinary 8-hydroxydeoxyguanine, and lifestyle factors.
Results:
The mean serum gamma-glutamyltransferase activity was 29 IU/L. Gamma-glutamyltransferase activities of males and persons older than 45 years were significantly higher than each counterpart. Gamma-glutamyltransferase levels increased significantly with the number of cigarettes smoked per day and the frequency of alcohol consumption except for the persons who did not take alcohol. Additionally, gamma-glutamyltransferase significantly correlated with urinary 8-hydroxydeoxyguanine, and with more blood factors including serum tocopherols, carotenoids, antioxidative enzymes, lipid peroxide, and free fatty acids than urinary 8-hydroxydeoxyguanine did. In multiple regression analyses, gamma-glutamyltransferase had significant associations with retinol, 8-hydroxydeoxyguanine, docosahexaenoic acid, and cigarette smoking.
Conclusions:
Our present findings support the hypothesis that gamma-glutamyltransferase can be used as a marker related with oxidative stress.
More Related Videos
Related Concept Videos
Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation
Several distinctive characteristics distinguish glutathione conjugation from other phase II...
Bioactivation and Tissue Toxicity

