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Related Experiment Video

Updated: Jul 4, 2026

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

Published on: December 19, 2019

Multiple cutaneous inverted papillomas in a dog.

E P Lane¹, U Tübbesing

¹Pathology Section, Department of Paraclinical Studies, Faculty of Veterinary Science, Private Bag X04, Onderstepoort, 0110 South Africa. emily@zoo.ac.za

Journal of the South African Veterinary Association

|May 30, 2008

Summary

A rare canine inverted papilloma case involved doughnut-shaped skin masses in a young dog. Histopathology revealed characteristic epithelial hyperplasia and hyperkeratosis.

Area of Science:

Veterinary Dermatology
Comparative Pathology

Background:

Canine papillomas are common viral-induced skin tumors.
Inverted papillomas are a less frequent variant, often affecting the oral mucosa.

Observation:

An 8-month-old mixed-breed dog presented with multiple, rapidly growing, firm, doughnut-shaped masses on its ventral abdomen.
The masses were located in Windhoek, Namibia.

Findings:

Histological examination revealed a cup-shaped rim of marked epithelial hyperplasia.
The center of the masses contained giant keratohyaline granules and prominent koilocytes.
Marked hyperkeratosis was a significant feature filling the central area of the lesions.

Implications:

This case expands the known clinical and geographical presentation of canine cutaneous inverted papillomas.

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Highlights the importance of histopathological confirmation for accurate diagnosis of canine skin tumors.

Contributes to the veterinary literature on less common papilloma variants in dogs.