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Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
Published on: October 22, 2014
Interarm blood pressure differences in the women's interagency HIV study
Jason Lazar1, Susan Holman, Howard L Minkoff
1Cardiovascular Medicine, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA. jason.lazar@downstate.edu
Large blood pressure differences between arms are common in women, regardless of HIV status. These differences, linked to cardiovascular risks like obesity, highlight the need for bilateral blood pressure measurement for accurate hypertension diagnosis.
Area of Science:
- Cardiovascular Health
- HIV Medicine
- Clinical Diagnostics
Background:
- Hypertension affects 8-32% of individuals with HIV.
- Large interarm blood pressure differences (IABPD) can lead to inaccurate blood pressure status classification.
- Accurate blood pressure measurement is crucial for managing hypertension and cardiovascular risk.
Purpose of the Study:
- To determine the magnitude of IABPD in HIV-infected women and uninfected controls.
- To identify factors associated with IABPD in this population.
- To assess the clinical significance of IABPD for hypertension detection and cardiovascular risk assessment.
Main Methods:
- Two automated blood pressure (BP) recordings were taken and averaged from each arm in 335 women (238 HIV-infected, 97 uninfected).
- Absolute IABPD was calculated for each participant.
- Statistical analyses were performed to identify associations between IABPD and various factors, including HIV status, CD4(+) cell count, antiretroviral therapy use, and cardiovascular risk factors.
Main Results:
- Mean systolic IABPD was 6 ± 5 mm Hg and mean diastolic IABPD was 4 ± 3 mm Hg.
- Twenty-six percent of subjects had systolic IABPD >10 mm Hg; 6% had systolic IABPD >20 mm Hg.
- Fifteen percent had diastolic IABPD >10 mm Hg.
- Systolic IABPD >20 mm Hg was associated with obesity and high LDL cholesterol.
- Bilateral BP measurement increased hypertension detection yield from 10% to 15% compared to single-arm measurement.
Conclusions:
- Systolic and diastolic IABPD are common and clinically significant in women, irrespective of HIV status.
- IABPD is associated with cardiovascular risk factors (obesity, high LDL) but not with HIV-related factors.
- Bilateral blood pressure measurement is essential for accurate hypertension detection, management, and cardiovascular risk assessment.
Related Concept Videos
Pre-Procedural Guidelines for Assessing Blood Pressure
Special considerations while measuring blood pressure
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
Assessment of blood pressure in brachial artery(two-step method)
Assessment of blood pressure in brachial artery(one-step method)
Prepare for the Procedure:
Sites for measuring blood pressure
The Brachial Artery: Primary Site for Blood Pressure Measurement
Measurement of Blood Pressure