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Updated: Jul 4, 2026
04:53
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
Effective strategies for implementing a multicenter international clinical trial
Leanne M Aitken1, Michele M Pelter, Beverly Carlson
1Research Centre for Clinical and Community Practice Innovation, Griffith University and Princess Alexandra Hospital, Brisbane, Australia. l.aitken@griffith.edu.au
Summary
Implementing a flexible yet structured approach across international research sites ensured the successful administration of a nursing educational intervention trial. This multicenter study effectively reduced prehospital delay in acute coronary syndrome (ACS) patients.
Area of Science:
- Global Health Research
- Clinical Trial Management
- Nursing Education
Background:
- International research collaboration is vital for advancing global health outcomes.
- Effective administration of multicenter trials requires robust strategies.
- Nursing interventions need testing in diverse settings to build an evidence base.
Purpose of the Study:
- To describe strategies for administering an international multicenter trial.
- To assess the effectiveness of a nursing educational intervention.
- To reduce prehospital delay in acute coronary syndrome (ACS) patients.
Main Methods:
- A two-group, randomized, multicenter international clinical trial design.
- Flexible project structure ensuring intervention consistency across five sites in three countries.
- Utilized experienced coordinators, multidimensional communication, fidelity strategies, local recruitment/retention, centralized data management, and addressed ethical/budgetary needs.
Main Results:
- Enrolled 3,522 participants across five international sites.
- Achieved 80% follow-up at both 12 and 24 months.
- Demonstrated successful implementation of a nursing educational intervention in a global context.
Conclusions:
- Multidimensional strategies balancing site consistency with local flexibility are key to successful international trials.
- The described approaches proved effective for conducting a multicenter international trial.
- Testing nursing interventions in multiple settings supports evidence-based practice development.
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