Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pedigree Analysis

Pedigree Analysis

Pedigree Analysis

Pedigree Analysis

Dihybrid Crosses

Dihybrid Crosses

Dihybrid Crosses

Dihybrid Crosses

Multiple Allele Traits

Multiple Allele Traits

The Concept of Multiple Allelism

Multiple Allele Traits

Multiple Allele Traits

The Concept of Multiple Allelism

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matter.

Nature aging·2026

Same author

Evidence for the Collective Nature of Radial Flow in Pb+Pb Collisions with the ATLAS Detector.

Physical review letters·2026

Same author

Evidence for the Dimuon Decay of the Higgs Boson in pp Collisions with the ATLAS Detector.

Physical review letters·2025

Same author

Evidence for Longitudinally Polarized W Bosons in the Electroweak Production of Same-Sign W Boson Pairs in Association with Two Jets in pp Collisions at sqrt[s]=13 TeV with the ATLAS Detector.

Physical review letters·2025

Same author

Observation of tt[over ¯] Production in Pb+Pb Collisions at sqrt[s_{NN}]=5.02 TeV with the ATLAS Detector.

Physical review letters·2025

Same author

Search for Dark Matter Produced in Association with a Dark Higgs Boson in the bb[over ¯] Final State Using pp Collisions at sqrt[s]=13 TeV with the ATLAS Detector.

Physical review letters·2025

Search research articles

Related Experiment Video

Updated: Jul 4, 2026

Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS): Guidelines for Sample Preparation and Normalization

Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS): Guidelines for Sample Preparation and Normalization

Published on: July 27, 2021

Exact trait-model-free tests for linkage detection in pedigrees.

S Basu¹, Y Di, E A Thompson

¹Division of Biostatistics, University of Minnesota, USA. saonli@umn.edu

Annals of Human Genetics

|May 30, 2008

Summary

A new permutation test offers efficient and robust linkage detection between genomic regions and traits. This trait-model-free method excels in complex pedigrees, even with inaccurate marker data.

More Related Videos

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Published on: February 3, 2013

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Related Experiment Videos

Last Updated: Jul 4, 2026

Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS): Guidelines for Sample Preparation and Normalization

Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS): Guidelines for Sample Preparation and Normalization

Published on: July 27, 2021

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Published on: February 3, 2013

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Area of Science:

Genetics
Statistical genetics
Bioinformatics

Background:

Trait-model-free tests are crucial for linkage detection in genomics.
Existing methods require complex modeling or are computationally intensive.

Purpose of the Study:

To introduce a computationally efficient permutation test for linkage detection.
To evaluate the performance and robustness of this new test against existing methods.

Main Methods:

Developed a permutation test for trait-linkage detection.
Applied the test to simulated datasets with complex multigeneration pedigrees.
Compared its performance with two existing exact trait-model-free tests.

Main Results:

The permutation test demonstrated high computational efficiency.
It proved robust against misspecified marker allele frequencies.
The test exhibited strong power for linkage detection.

Conclusions:

The proposed permutation test is a viable and powerful alternative for linkage detection.
Its efficiency and robustness make it suitable for complex genetic studies.
The test is implemented in the lm_ibdtests program within MORGAN 2.8.