Search research articles

Related Concept Videos

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Diabetic Retinopathy

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

Diabetic Nephropathy

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Update on the structure-function relationship in glaucoma.

Survey of ophthalmology·2026

Same author

Local Versus Global Binarization Techniques After Frangi Filtering for Optical Coherence Tomography Angiography Based Retinal Vessel Density Assessment in Diabetic Retinopathy.

Diagnostics (Basel, Switzerland)·2026

Same author

Longitudinal investigation of spatial memory and retinal parameters in a 5xFAD model of Alzheimer's disease reveals differences dependent on genotype and sex.

Biomedical optics express·2026

Same author

Grading Scales of Conjunctival Inflammation.

Diagnostics (Basel, Switzerland)·2025

Same author

Shear-Stress-Dependent Viscous Properties of Hyaluronic-Based Lubricants.

Journal of clinical medicine·2025

Same author

Outcome parameters in studies investigating dry eye disease: A systematic literature review.

Acta ophthalmologica·2025

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 4, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Endothelial dysfunction in glaucoma.

Hemma Resch¹, Gerhard Garhofer, Gabriele Fuchsjäger-Mayrl

¹Department of Clinical Pharmacology, Medical University, Vienna, Austria.

Acta Ophthalmologica

|May 30, 2008

Summary

This summary is machine-generated.

Glaucoma involves optic nerve damage and vision loss, often linked to high eye pressure. This review explores how endothelial dysfunction, affecting blood vessels, contributes to glaucoma and may offer new treatment targets.

More Related Videos

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

An Acute Retinal Model for Evaluating Blood Retinal Barrier Breach and Potential Drugs for Treatment

An Acute Retinal Model for Evaluating Blood Retinal Barrier Breach and Potential Drugs for Treatment

Published on: September 13, 2016

Related Experiment Videos

Last Updated: Jul 4, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

An Acute Retinal Model for Evaluating Blood Retinal Barrier Breach and Potential Drugs for Treatment

An Acute Retinal Model for Evaluating Blood Retinal Barrier Breach and Potential Drugs for Treatment

Published on: September 13, 2016

Area of Science:

Ophthalmology
Vascular Biology
Neuroscience

Background:

Glaucoma is characterized by optic neuropathy, retinal nerve fiber layer loss, and visual field defects.
Elevated intraocular pressure is a primary risk factor, but glaucoma pathogenesis is multifactorial, involving ischemia and vascular dysregulation.
The vascular endothelium regulates ocular blood flow, and its dysfunction can lead to ocular ischemia.

Purpose of the Study:

To review current evidence on endothelial dysfunction in glaucoma.
To highlight the potential of endothelial dysfunction as a therapeutic target for glaucoma management.

Main Methods:

Literature review of studies investigating endothelial function in glaucoma patients.
Analysis of the role of vascular endothelium in ocular blood flow regulation and glaucoma pathogenesis.

Main Results:

Pathological alterations in vascular endothelial cells are implicated in glaucoma's ischemic mechanisms.
Endothelial dysfunction is a known prognostic factor for disease progression in other conditions.

Conclusions:

Endothelial dysfunction is a significant factor in glaucoma pathogenesis.
Targeting endothelial dysfunction may offer a novel therapeutic strategy for open-angle glaucoma and other ocular vascular disorders.