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Updated: Jul 4, 2026

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

TRP channel and cardiovascular disease

Hiroyuki Watanabe1, Manabu Murakami, Takayoshi Ohba

  • 1Second Department of Internal Medicine, Akita University School of Medicine 1-1-1, Hondoh, Akita 010-8543, Japan.

Pharmacology & Therapeutics
|May 30, 2008
PubMed

Insights

Transient Receptor Potential (TRP) channels are key sensors in cardiovascular cells. This review explores their pathological roles in heart failure, arrhythmias, and vascular diseases, identifying them as potential therapeutic targets.

Area of Science:

  • Cardiovascular Physiology
  • Molecular Biology
  • Pharmacology

Background:

  • Transient Receptor Potential (TRP) channels are a superfamily of mammalian cation channels.
  • Expressed in cardiac and vascular tissues, they function as cellular sensors involved in contraction, proliferation, and cell death.
  • TRP channels are implicated as store-operated, receptor-operated, ligand-gated, and stretch-activated channels.

Purpose of the Study:

  • To review the pathological roles of TRP channels in cardiovascular diseases.
  • To highlight specific TRP channels involved in cardiac and vascular dysfunction.
  • To identify TRP channels as potential pharmacological targets for cardiovascular diseases.

Main Methods:

  • Literature review of current knowledge on TRP channels in cardiovascular pathology.
  • Analysis of evidence linking specific TRP channel subtypes to disease mechanisms.
  • Identification of TRP channels with anticipated roles in cardiovascular diseases.

Main Results:

  • TRPC channel upregulation is linked to cardiac hypertrophy and heart failure.
  • TRPM4 contributes to cardiac arrhythmias.
  • TRPC channels are associated with vascular remodeling and pulmonary hypertension.
  • TRPV4 dysfunction impairs vasorelaxation; TRPC3/C4 and TRPM2 are endothelial redox sensors.
  • TRPC1, -C4, -C6, -V4, and -M2 are implicated in endothelial barrier dysfunction.

Conclusions:

  • TRP channels play significant pathological roles in cardiovascular diseases.
  • Specific TRP channel subtypes are crucial in conditions like heart failure, arrhythmias, and vascular dysfunction.
  • TRP channels represent promising novel pharmacological targets for treating cardiovascular diseases.

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