Development of novel statistical reconstruction algorithms for poly-energetic X-ray computed tomography
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3D Imaging of Soft-Tissue Samples using an X-ray Specific Staining Method and Nanoscopic Computed Tomography
Published on: October 24, 2019
Ho-Shiang Chueh1, Wen-Kai Tsai, Chih-Chieh Chang
1Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ROC.
Abstract:
A beam-hardening effect is a common problem affecting the quantitative aspects of X-ray computed tomography (CT). We have developed two statistical reconstruction algorithms for poly-energetic X-ray CT that can effectively reduce the beam-hardening effect. Phantom tests were used to evaluate our approach in comparison with traditional correction methods. Unlike previous methods, our algorithm utilizes multiple energy-corresponding blank scans to estimate the attenuation map for a particular energy spectrum. Therefore, our algorithm is an energy-selective reconstruction. In addition to benefits over other statistical algorithms for poly-energetic reconstruction, our algorithm has the advantage of not requiring prior knowledge of the object material, the energy spectrum of the source and the energy sensitivity of the detector. The results showed an improvement in coefficient of variation, uniformity and signal-to-noise ratio; overall, this novel approach produces a better beam-hardening correction.
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