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Related Experiment Video

Updated: Jul 4, 2026

Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity (AIDN): A Translational Neuroscience Approach

Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity (AIDN): A Translational Neuroscience Approach

Published on: June 11, 2017

Cellular genesis in the postnatal piglet.

Andrew O Koob¹, Brent T Harris, Ann-Christine Duhaime

¹Department of Pediatric Neurosurgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, United States. koob@ucsd.edu

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience

|May 30, 2008

Summary

This summary is machine-generated.

This study characterizes postnatal cellular genesis in piglet brains, a valuable model for human neurobiology. Researchers identified significant cell generation in the subventricular zone using BrdU and DCX markers.

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Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity (AIDN): A Translational Neuroscience Approach

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Culture of Piglet Intestinal 3D Organoids from Cryopreserved Epithelial Crypts and Establishment of Cell Monolayers

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Published on: February 10, 2023

Area of Science:

Neuroscience
Developmental Neuroscience
Comparative Neuroanatomy

Background:

Piglet brains offer anatomical and developmental similarities to human brains.
Validating piglet models is crucial for advancing neurobiological research.
Understanding postnatal neurogenesis is key to brain development and repair.

Purpose of the Study:

To characterize areas of postnatal cellular genesis in the piglet brain.
To validate the piglet as a model for neurobiological studies.
To establish methods for studying neurogenesis in piglets.

Main Methods:

Utilized immunohistochemistry for 5-bromodeoxyuridine (BrdU) and doublecortin (DCX).
Injected four piglets with BrdU at 6, 7, and 8 days of age.
Analyzed brains at 13 days of age for cellular genesis markers.

Main Results:

BrdU-positive cells were detected throughout the piglet brain.
The subventricular zone (SVZ) showed the highest abundance of BrdU.
Extensive doublecortin (DCX) expressing cells and networks were observed in the SVZ and white matter.

Conclusions:

Immunohistochemistry for BrdU and DCX effectively visualizes cellular genesis in the piglet brain.
The study confirms the piglet brain as a suitable model for neurobiological research.
Significant postnatal neurogenesis occurs in specific regions of the piglet brain, particularly the SVZ.