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Updated: Jul 4, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
Published on: December 10, 2021
Trimeric G protein-dependent signaling by Frizzled receptors in animal development
Diane Egger-Adam1, Vladimir L Katanaev
1Department of Biology, University Konstanz, P.O. Box 643, 78457 Konstanz, Germany.
Abstract:
Receptors of the Frizzled family transduce important signals during animal development and are conserved from sponges to humans. Frizzled receptors belong to the superfamily of G protein-coupled receptors (GPCRs), but until recently were considered G protein-independent in their signaling. In the present article we review the extensive knowledge demonstrating the functions of trimeric G proteins in Frizzled signal transduction in vertebrates and lower animals. Other structural and functional similarities of Frizzled receptors and the GPCRs are also discussed.
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