Related Experiment Video
Updated: Jul 4, 2026

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
The role of chemokines during herpes simplex virus-1 infection
Todd R Wuest1, Daniel J J Carr
1Department of Microbiology, Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Abstract:
Herpes simplex virus-type 1 is among the most prevalent and successful humans pathogens. Although infection is largely uncomplicated in the immunocompetent human host, HSV-1 infection can cause blinding corneal disease, and individuals with defects in innate or adaptive immunity are susceptible to herpes simplex encephalitis. Chemokines regulate leukocyte trafficking to inflamed tissues and play a crucial role in orchestrating the immune response to HSV-1 infection. In this review we will focus on the pathways that induce chemokine expression during HSV-1 infection and the implications of chemokine signaling on control of viral replication.
More Related Videos
Related Concept Videos
Herpes
Genital Herpes
Cytomegalovirus Disease
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Chickenpox
Chemotaxis and Direction of Cell Migration

