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Updated: Jul 4, 2026
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Time-resolved Förster Resonance Energy Transfer Assays for Measurement of Endogenous Phosphorylated STAT Proteins in Human Cells
Published on: September 9, 2021
Protein tyrosine phosphatases in the JAK/STAT pathway
1Department of Medicine, Division of Hematology/Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Summary
Protein tyrosine phosphatases (PTPs), especially SHP2, are key regulators of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Understanding PTPs is vital for addressing immune and blood disorders linked to JAK/STAT pathway dysfunction.
Area of Science:
- Cellular signaling
- Molecular biology
- Immunology
Background:
- The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway regulates cellular responses to cytokines.
- Dysregulation of the JAK/STAT pathway is implicated in hematopoietic and immune disorders.
- Protein tyrosine kinases and phosphatases (PTPs) control JAK/STAT signaling through phosphorylation and dephosphorylation.
Purpose of the Study:
- To review recent advances in understanding the regulatory roles of PTPs in the JAK/STAT signaling pathway.
- To highlight the specific involvement of SHP2 phosphatase in JAK/STAT pathway regulation.
Main Methods:
- Literature review of recent research on PTPs and JAK/STAT signaling.
- Focus on studies investigating the function of SHP2 phosphatase.
Main Results:
- PTPs play critical roles in modulating JAK/STAT pathway activity.
- SHP2 phosphatase is a significant regulator within this pathway.
- Specific mechanisms of SHP2 action in JAK/STAT signaling are being elucidated.
Conclusions:
- PTPs, particularly SHP2, are essential for maintaining homeostasis in the JAK/STAT pathway.
- Further research into PTPs offers therapeutic potential for JAK/STAT-related diseases.
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