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Related Concept Videos

Morphogenesis02:19

Morphogenesis

Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
Mechanism of Lamellipodia Formation01:31

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Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
Cell Adhesion Molecules - Types and Functions01:20

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Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
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Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...

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Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
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Published on: January 30, 2014

EpCAM in morphogenesis.

Monika Trzpis1, Edwin Bremer, Pamela M J McLaughlin

  • 1University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Frontiers in Bioscience : a Journal and Virtual Library
|May 30, 2008
PubMed
Summary
This summary is machine-generated.

The Epithelial Cell Adhesion Molecule (EpCAM) is crucial for embryonic development, influencing cell adhesion, proliferation, migration, and differentiation. This review highlights EpCAM's vital role in morphogenesis from early embryogenesis through organogenesis.

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Area of Science:

  • Developmental Biology
  • Cell Biology
  • Molecular Biology

Background:

  • Embryonic development relies on complex protein interactions, including cell adhesion molecules (CAMs).
  • Epithelial Cell Adhesion Molecule (EpCAM), initially a carcinoma marker, has diverse functions beyond cell adhesion.
  • CAMs are critical for the precise execution of embryonic development.

Purpose of the Study:

  • To review the literature on EpCAM's role in morphogenesis during embryonic development.
  • To elucidate EpCAM's involvement from early embryogenesis to organogenesis.
  • To suggest future research directions for understanding EpCAM in embryogenesis.

Main Methods:

  • Literature review of existing studies on EpCAM function.
  • Analysis of EpCAM's involvement in cell adhesion, proliferation, migration, and differentiation.
  • Synthesis of findings related to EpCAM's role in morphogenesis.

Main Results:

  • EpCAM is implicated in fundamental processes of morphogenesis.
  • EpCAM's functions extend to cell proliferation, migration, and differentiation.
  • EpCAM plays a role throughout embryonic development, from initial stages to organogenesis.

Conclusions:

  • EpCAM is a key protein involved in embryonic morphogenesis.
  • EpCAM's multifaceted roles are essential for proper embryonic development.
  • Further research is needed to fully understand EpCAM's embryogenic functions.