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Updated: Jul 4, 2026
11:12
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
Does deep brain stimulation induce apathy in Parkinson's disease?
Lindsey Kirsch-Darrow1, Ania Mikos, Dawn Bowers
1University of Florida Department of Clinical and Health Psychology, P.O. Box 100165, Gainesville, FL 32610, USA.
Summary
Deep brain stimulation (DBS) helps Parkinson's motor symptoms but can cause apathy. This review examines DBS and apathy, highlighting research gaps and future directions for understanding this side effect.
Area of Science:
- Neuroscience
- Neurology
- Psychiatry
Background:
- Deep brain stimulation (DBS) is a key therapy for Parkinson's disease (PD) motor symptoms.
- The impact of DBS on non-motor symptoms, particularly apathy, remains unclear.
- Existing research suggests a link between DBS and increased apathy post-surgery.
Purpose of the Study:
- To review and evaluate current literature on apathy following DBS in Parkinson's disease patients.
- To identify and discuss methodological limitations in existing studies.
- To propose directions for future research on DBS and apathy.
Main Methods:
- Systematic literature review.
- Critical evaluation of studies examining apathy after DBS for Parkinson's disease.
- Analysis of methodological approaches and findings.
Main Results:
- Evidence suggests a correlation between DBS and apathy in Parkinson's disease patients.
- Significant heterogeneity exists in study designs and outcome measures.
- Methodological limitations hinder definitive conclusions regarding causality.
Conclusions:
- Apathy is a recognized concern after DBS surgery for Parkinson's disease.
- Further rigorous research is needed to clarify the relationship between DBS and apathy.
- Standardized methodologies are crucial for future investigations.
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