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Updated: Jul 4, 2026

Rapid and Robust Analysis of Cellular and Molecular Polarization Induced by Chemokine Signaling

Rapid and Robust Analysis of Cellular and Molecular Polarization Induced by Chemokine Signaling

Published on: December 12, 2014

Chemokines: coded messages for T-cell missions.

Antonella Viola¹, Barbara Molon, Rita Lucia Contento

¹Istituto Clinico Humanitas I.R.C.C.S.,Via Manzoni 56, 20089 Rozzano, Milan, Italy. antonella.viola@humanitas.it

Frontiers in Bioscience : a Journal and Virtual Library

|May 30, 2008

Summary

This summary is machine-generated.

Chemokines and their receptors guide T-cells for immune responses. They control T-cell development, priming, and effector functions, influencing immune cell migration and polarization.

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Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

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Published on: September 20, 2019

Area of Science:

Immunology
Cell Biology

Background:

Chemokines and their receptors are crucial for leukocyte migration and homing.
They play a vital role in both normal physiological processes and disease states.
In adaptive immunity, they provide precise spatial and temporal guidance for T-cells.

Purpose of the Study:

To review the multifaceted roles of chemokines in T-cell biology.
To elucidate how chemokines orchestrate T-cell development, priming, and effector functions.
To discuss the direct modulatory effects of chemokines on T-cell responses.

Main Methods:

Literature review of studies on chemokines and T-cell interactions.
Analysis of the spatio-temporal guidance provided by chemokines.
Examination of chemokine-mediated signaling at the immune synapse.
Review of chemokine influence on T-helper cell polarization (Th1/Th2).

Main Results:

Chemokines act as a versatile code, dictating the "who, where, and when" of immune responses.
They provide essential chemotactic signals for T-cell trafficking.
Chemokines amplify signals at the immune synapse and modulate Th1/Th2 polarization.

Conclusions:

Chemokines are indispensable regulators of T-cell life cycle and function.
Their roles extend beyond chemotaxis to direct modulation of T-cell responses.
Understanding chemokine involvement is key to comprehending adaptive immunity.