Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolutionary characterization of lung cancer metastasis.

Nature·2026
Same author

Mesothelioma: a systemic therapy clinical trials snapshot.

Trends in cancer·2026
Same author

BAP1-loss in mesothelioma: molecular mechanisms and clinical opportunities.

Oncogene·2026
Same author

Bioinspired Synthesis of Twin abeo-Steroids Bufogargarizins A and B via a Divergent Intramolecular Aldol Addition Reaction.

Angewandte Chemie (International ed. in English)·2025
Same author

Longitudinal ultrasensitive ctDNA monitoring for high-resolution lung cancer risk prediction.

Cell·2025
Same author

Discovery of actionable drug targets to enhance T-cell infiltration and immune checkpoint blockade efficacy in pleural mesothelioma.

Lung cancer (Amsterdam, Netherlands)·2025

Related Experiment Video

Updated: Jul 4, 2026

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model
06:12

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model

Published on: May 29, 2015

Exploiting BH3 only protein function for effective cancer therapy.

Dean A Fennell1, Alex Chacko

  • 1Centre for Cancer Research and Cell Biology, Queen's University Belfast, Northern Ireland. d.fennell@qub.ac.uk

Frontiers in Bioscience : a Journal and Virtual Library
|May 30, 2008
PubMed
Summary
This summary is machine-generated.

Targeted cancer therapies using BH3-only proteins show promise in overcoming drug resistance. Understanding these proteins

Related Experiment Videos

Last Updated: Jul 4, 2026

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model
06:12

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model

Published on: May 29, 2015

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Conventional chemotherapy often fails to induce selective cancer cell death, limiting treatment efficacy.
  • Drug resistance in solid tumors is a significant barrier to improving patient survival.
  • Understanding cell death signaling pathways is crucial for developing better cancer treatments.

Purpose of the Study:

  • To review the role of BH3-only proteins in cancer cell death.
  • To explore how BH3-only proteins mediate cell death via BAX and BAK.
  • To discuss the development of targeted agents based on this knowledge.

Main Methods:

  • Literature review of studies on BH3-only proteins and apoptosis.
  • Analysis of signaling pathways involved in drug resistance.
  • Examination of novel targeted cancer therapies.

Main Results:

  • BH3-only proteins are key mediators of apoptosis through BAX and BAK.
  • Dysregulation of these proteins contributes to chemotherapy resistance.
  • Targeted agents modulating BH3-only proteins demonstrate significant cancer cell killing efficacy.

Conclusions:

  • BH3-only proteins are critical regulators of cancer cell death.
  • Targeted therapies focusing on BH3-only proteins offer a promising strategy to overcome drug resistance.
  • Further research into these pathways can lead to improved cancer survival rates.