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Updated: Jul 4, 2026

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
Published on: August 5, 2017
Contextual specificity of extinction of delay but not trace eyeblink conditioning in humans
Christian Grillon1, Ruben P Alvarez, Linda Johnson
1Mood & Anxiety Disorders Program, National Institute of Mental Health, NIH, Bethesda, Maryland 20892, USA. christian.grillon@nih.gov
Abstract:
Renewal of an extinguished conditioned response has been demonstrated in humans and in animals using various types of procedures, except renewal of motor learning such as eyeblink conditioning. We tested renewal of delay and trace eyeblink conditioning in a virtual environment in an ABA design. Following acquisition in one context (A, e.g., an airport) and extinction in a different context (B, e.g., a city), tests for renewal took place in the acquisition (A) and extinction context (B), in a counterbalanced order. Results showed renewal of the extinguished conditioned response in the delay but not trace condition.
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