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Related Experiment Video

Updated: Jul 4, 2026

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

Endothelial function in patients with proteinuric primary glomerulonephritis.

Bruce Mackinnon¹, Christopher J Deighan, William R Ferrell

¹Renal Unit, Glasgow Royal Infirmary, Glasgow, UK. bmackinnon@hotmail.com

Nephron. Clinical Practice

|May 30, 2008

Summary

Endothelial function and vascular smooth muscle function are impaired in patients with early-stage kidney disease, even before significant renal decline. These findings highlight early vascular dysfunction in primary glomerulonephritis.

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Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Last Updated: Jul 4, 2026

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Area of Science:

Nephrology and Cardiovascular Research
Vascular Biology and Physiology

Background:

Cardiovascular disease is a leading cause of mortality in end-stage renal disease patients.
Endothelial dysfunction and inflammation are implicated in atherosclerosis progression.
Early assessment of endothelial function in renal disease is crucial.

Purpose of the Study:

To evaluate endothelial function in the early stages of renal disease.
To investigate microvascular endothelial function in patients with primary glomerulonephritis.

Main Methods:

Recruitment of patients with primary glomerulonephritis and healthy controls.
Assays for C-reactive protein (CRP), von Willebrand Factor (vWF), VCAM, and ICAM.
Laser Doppler imaging for direct assessment of microvascular endothelial function.

Main Results:

Significantly elevated levels of ICAM, VCAM, and vWF in patients compared to controls.
Blunted endothelium-dependent and independent vascular responses in patients.
Findings were significant after adjusting for blood pressure and BMI.

Conclusions:

Microvascular endothelial and vascular smooth muscle function are abnormal in patients with primary glomerulonephritis and moderate proteinuria.
These abnormalities exist despite well-maintained renal function.
The study provides insights into early vascular changes in kidney disease, free from confounding medication effects.