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Related Experiment Videos

Pediatric fine-needle aspiration biopsy.

J F Silverman1, A M Gurley, C T Holbrook

  • 1Department of Pathology and Laboratory Medicine, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354.

American Journal of Clinical Pathology
|May 1, 1991
PubMed
Summary

Pediatric fine-needle aspiration (FNA) biopsies are highly accurate for diagnosing neoplastic and infectious diseases in children. This minimally invasive procedure aids in treatment planning and demonstrates high sensitivity and specificity.

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Area of Science:

  • Pediatric Pathology
  • Cytopathology
  • Oncology

Background:

  • Fine-needle aspiration (FNA) biopsy is a valuable diagnostic tool in pediatric medicine.
  • Accurate diagnosis is crucial for effective treatment of pediatric diseases, including neoplasms and infections.

Purpose of the Study:

  • To evaluate the diagnostic accuracy and utility of FNA biopsies in a pediatric population.
  • To assess the role of FNA in managing pediatric neoplastic and infectious diseases.

Main Methods:

  • Retrospective review of 135 FNA biopsies from 123 children over five years.
  • Analysis of diagnostic yield, including neoplastic and nonneoplastic conditions.
  • Evaluation of ancillary studies such as immunocytochemistry, electron microscopy, and flow cytometry.

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Main Results:

  • 96.3% of specimens were satisfactory for evaluation.
  • 79 cases (60.8%) were nonneoplastic, with 17 (13.1%) diagnosed as infectious diseases.
  • 50 cases (38.5%) were neoplastic (14 benign, 28 malignant, 8 uncertain).
  • High diagnostic performance: 90.6% sensitivity, 100% specificity, 96.5% efficiency.
  • Four false-negative diagnoses, three involving central nervous system (CNS) aspirates.

Conclusions:

  • Pediatric FNA biopsy is a safe and effective method for diagnosing a wide range of pediatric conditions.
  • The procedure facilitates timely treatment decisions, including chemotherapy, radiation, and surgical planning.
  • Ancillary studies enhance diagnostic specificity and provide critical information for patient management.