Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A critical review of wire injury induced aortic valve stenosis in mice.

Journal of molecular and cellular cardiology·2022
Same author

CCR7-guided neutrophil redirection to skin-draining lymph nodes regulates cutaneous inflammation and infection.

Science immunology·2022
Same author

A systematic electron microscopic study on the uptake of barium sulphate nano-, submicro-, microparticles by bone marrow-derived phagocytosing cells.

Acta biomaterialia·2018
Same author

[New insights into the function of bone marrow].

Zeitschrift fur Rheumatologie·2018
Same author

[Mutual influence of immune system and bones].

Zeitschrift fur Rheumatologie·2018
Same author

Selective detection of NADPH oxidase in polymorphonuclear cells by means of NAD(P)H-based fluorescence lifetime imaging.

Journal of biophysics (Hindawi Publishing Corporation : Online)·2010

Related Experiment Video

Updated: Jul 4, 2026

Real-Time In Vitro Migration Assay for Primary Murine CD8+ T Cells
06:42

Real-Time In Vitro Migration Assay for Primary Murine CD8+ T Cells

Published on: May 24, 2024

Migration, cell-cell interaction and adhesion in the immune system.

M Gunzer1

  • 1Institute of Immunology, Otto-von-Gericke University Magdeburg, Leipziger Strasse 44, D-39120 Magdeburg, Germany. Matthias.gunzer@med.ovgu.de

Ernst Schering Foundation Symposium Proceedings
|May 31, 2008
PubMed
Summary

Cellular dynamics are crucial for both innate and adaptive immunity, involving complex migration and interaction events. This review focuses on recent microscopic observations of live immune cells to understand these essential processes.

More Related Videos

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
07:40

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions

Published on: June 29, 2016

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
09:14

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

Related Experiment Videos

Last Updated: Jul 4, 2026

Real-Time In Vitro Migration Assay for Primary Murine CD8+ T Cells
06:42

Real-Time In Vitro Migration Assay for Primary Murine CD8+ T Cells

Published on: May 24, 2024

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
07:40

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions

Published on: June 29, 2016

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
09:14

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

Area of Science:

  • Immunology
  • Cell Biology
  • Microscopy

Background:

  • Immune cell migration is vital for development, activation, and function in both innate and adaptive immunity.
  • Immune cells navigate complex pathways, interacting with tissues and each other to mount effective responses.
  • Understanding cellular dynamics is key to comprehending immune system functionality.

Purpose of the Study:

  • To review the central aspects of cellular dynamics in adaptive and innate immunity.
  • To highlight recent findings from live cell imaging techniques.
  • To elucidate the mechanisms of immune cell migration, interaction, and extravasation.

Main Methods:

  • In vitro live cell microscopy.
  • Intravital 2-photon microscopy in live animals.
  • Analysis of cellular dynamics and interactions.

Main Results:

  • Immune cell migration involves intricate sequences of adhesion, signaling, and movement.
  • Both innate and adaptive immune cells exhibit dynamic behaviors essential for pathogen defense and tissue homeostasis.
  • Microscopic techniques provide unprecedented insights into real-time immune cell functions.

Conclusions:

  • Cellular dynamics, particularly migration and interaction, are fundamental to immune responses.
  • Live imaging technologies are revolutionizing our understanding of immune cell behavior.
  • Further research into these dynamics will advance immunology and therapeutic strategies.