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Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...
Autophagic Cell Death01:18

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...

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Related Experiment Video

Updated: Jul 4, 2026

Stimulating and Analyzing Adult Neurogenesis in the Drosophila Central Brain
06:31

Stimulating and Analyzing Adult Neurogenesis in the Drosophila Central Brain

Published on: October 8, 2021

Forever young: death-defying neuroblasts.

James M Chell1, Andrea H Brand

  • 1The Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

Cell
|May 31, 2008
PubMed
Summary

Neural stem cells age during development, generating different cell types. Maurange et al. identified factors in Drosophila neuroblasts that control progeny fate and stop stem cell proliferation.

Area of Science:

  • Developmental biology
  • Neuroscience
  • Cell biology

Background:

  • Neural stem cells (NSCs) undergo aging during development.
  • This aging process involves the sequential generation of distinct neuronal and glial cell types.
  • Understanding the mechanisms of NSC aging is crucial for developmental processes.

Discussion:

  • Maurange et al. investigated temporal control factors in Drosophila neural stem cells (neuroblasts).
  • These factors regulate the fate of cells produced by the stem cell.
  • The study identifies signals that indicate the end of stem cell proliferation.

Key Insights:

  • Identification of specific temporal control factors in Drosophila neuroblasts.
  • Demonstration of these factors' role in regulating stem cell progeny fate.

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Live Imaging of Drosophila Larval Neuroblasts
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Live-Cell Imaging of Drosophila melanogaster Third Instar Larval Brains
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Live-Cell Imaging of Drosophila melanogaster Third Instar Larval Brains

Published on: June 23, 2023

Related Experiment Videos

Last Updated: Jul 4, 2026

Stimulating and Analyzing Adult Neurogenesis in the Drosophila Central Brain
06:31

Stimulating and Analyzing Adult Neurogenesis in the Drosophila Central Brain

Published on: October 8, 2021

Live Imaging of Drosophila Larval Neuroblasts
09:50

Live Imaging of Drosophila Larval Neuroblasts

Published on: July 7, 2014

Live-Cell Imaging of Drosophila melanogaster Third Instar Larval Brains
07:06

Live-Cell Imaging of Drosophila melanogaster Third Instar Larval Brains

Published on: June 23, 2023

  • Discovery of mechanisms signaling the cessation of stem cell proliferation.

    • Outlook:

    • Further research into conserved mechanisms of stem cell aging across species.
    • Implications for understanding neurodevelopmental disorders.
    • Potential applications in regenerative medicine and stem cell therapies.