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Monochrome Multiplex Quantitative PCR Telomere Length Measurement

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Published on: March 22, 2024

Total TEQ reference range (PCDDs, PCDFs, cPCBs, mono-PCBs) for the US population 2001-2002.

Donald G Patterson¹, Wayman E Turner, Samuel P Caudill

¹Organic Analytical Toxicology Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Mail Stop F-17, Atlanta, GA 30341, United States. donpatt@etcmail.com

|May 31, 2008

Summary

This study establishes reference ranges for toxic equivalency (TEQ) levels in the U.S. population, revealing lower levels with 2005 TEF values and significant variations by age, sex, and race/ethnicity.

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Published on: December 6, 2014

Area of Science:

Environmental Chemistry
Toxicology
Public Health

Background:

Polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and biphenyls (PCBs) are persistent organic pollutants with significant health implications.
Accurate reference ranges are crucial for assessing population exposure and health risks associated with these contaminants.
Previous assessments may not reflect current exposure levels or utilize updated toxic equivalency factors (TEFs).

Purpose of the Study:

To establish reference ranges for total toxic equivalency (TEQ) and TEQ sub-fractions of PCDDs, PCDFs, coplanar biphenyls (cPCBs), and mono-ortho-substituted biphenyls (mPCBs) in the U.S. population.
To stratify these TEQ levels by age, sex, and race/ethnicity.
To compare TEQ levels derived from 1998 and 2005 TEF values.

Main Methods:

Statistically designed sampling of the U.S. population conducted in 2001-2002.
Measurement of TEQ and TEQ sub-fractions for PCDDs, PCDFs, cPCBs, and mPCBs.
Stratification of data by age, sex, race/ethnicity, and comparison of 1998 vs. 2005 TEF values.

Main Results:

TEQ levels were lower using the 2005 TEFs compared to 1998 TEFs, primarily due to revised mPCB values.
Mexican Americans exhibited significantly lower TEQ levels than non-Hispanic whites and non-Hispanic blacks.
TEQ levels showed a significant increase with age across most demographic groups, with distinct patterns in younger populations.

Conclusions:

The 2005 TEFs result in lower overall TEQ estimates, highlighting the impact of updated toxicity values.
Significant demographic variations in TEQ levels underscore the need for tailored public health assessments.
Age is a significant factor influencing TEQ levels and the relative contribution of different contaminant classes.