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Updated: Jul 4, 2026

Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0
Published on: June 5, 2017
Adaptive properties and heterogeneity of dopamine D(2) receptors - pharmacological implications
Arvid Carlsson1, Maria L Carlsson
1Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Arvid.Carlsson@pharm.gu.se
Abstract:
In this review, we focus on the marked adaptability of dopamine D(2) receptors to varying agonist levels and we discuss the extent to which this phenomenon can account for the heterogeneity of these receptors in regard to function and pharmacological responsiveness. We emphasize the significance of a distinction between synaptic and extrasynaptic receptors in this context. For example, the application of this dichotomy appears to shed new light on the various subgroups of antipsychotic drugs and the mechanisms underlying their different profiles.
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