Related Experiment Video
Updated: Jul 4, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
Published on: June 26, 2018
Systems genetics can provide new insights in to immune regulation and autoimmunity
Grant Morahan1, Violet Peeva, Munish Mehta
1The University of Western Australia, Perth, WA 6000, Australia. gem@waimr.uwa.edu.au
Abstract:
"Systems Genetics" detects variation in phenotypic traits and integrates this with underlying genetic variation. A powerful application of systems genetics is analyzing effects of genome-wide genetic variants on transcriptome-wide variation in gene expression. We see systems genetics as a new powerful technology which will empower research in genetics and in other disciplines. Here, we present preliminary analyses of systems genetics approaches to defining genetic interactions within the thymus, which is the key site for T lymphocyte development and imposition of immunological tolerance.
Related Concept Videos
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune system...
What is the Immune System?
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Pharmacogenomics: Identification of New Drug Targets
Cell-mediated Immune Responses
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
