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Antipsychotic Drugs: Typical and Atypical Agents01:21

Antipsychotic Drugs: Typical and Atypical Agents

Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antipsychotic Drugs: Therapeutic Uses and Side Effects01:21

Antipsychotic Drugs: Therapeutic Uses and Side Effects

Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...

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Related Experiment Video

Updated: Jul 4, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

Do we need another atypical antipsychotic?

Siegfried Kasper1

  • 1Department of Psychiatry and Psychotherapy, Medical University of Vienna, Wein, Austria. sci-genpsy@meduniwien.ac.at

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
|May 31, 2008
PubMed
Summary

Sertindole, an atypical antipsychotic, shows a favorable safety profile and potential benefits for schizophrenia patients switching from other medications. Post-marketing studies support its reintroduction for individualized treatment.

Related Experiment Videos

Last Updated: Jul 4, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Atypical antipsychotics offer advancements in schizophrenia treatment, yet no single agent provides optimal efficacy and safety for all patients.
  • Individualized treatment selection remains crucial, relying on clinical experience to navigate patient-specific needs.

Purpose of the Study:

  • To evaluate the safety and efficacy of sertindole following its suspension and reintroduction.
  • To identify patient subgroups who may benefit from switching to sertindole from other atypical antipsychotics.

Main Methods:

  • Post-marketing studies were conducted in clinical settings to gather safety and efficacy data for sertindole.
  • Analysis focused on treatment-emergent effects, safety profiles, and patient outcomes after switching medications.

Main Results:

  • Post-marketing data support the reintroduction of sertindole.
  • Specific patient populations demonstrated benefits when switching to sertindole from other atypical antipsychotics.
  • Sertindole exhibits an individual and generally favorable profile of treatment-emergent effects and safety, allowing for flexible patient management.

Conclusions:

  • Sertindole's favorable safety and efficacy profile, with a low propensity for troublesome anticholinergic effects, supports its use in schizophrenia treatment.
  • Emerging evidence suggests potential cognitive benefits of sertindole, warranting further investigation.
  • Sertindole offers a valuable, flexible option for individualized schizophrenia therapy.