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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

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Therapeutic Massage for Psychological Well-being in Geriatric Oncology
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Therapeutic Massage for Psychological Well-being in Geriatric Oncology

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[Aging and geriatric oncology].

Olivier Saint-Jean1, Hayat Lahjibi-Paulet, Mouna Maamar

  • 1Service de gériatrie, Hôpital européen Georges Pompidou, 20, rue Leblanc, 75015 Paris, France. olivier.saint-jean@egp.aphp.fr

Bulletin Du Cancer
|December 17, 2008
PubMed
Summary

Chronologic age is not the sole determinant for treating older adults. Evaluating health, autonomy, and diseases is crucial for personalized geriatric care and improved outcomes.

Area of Science:

  • Geriatric Medicine
  • Oncology
  • Aging Research

Context:

  • Chronologic age is insufficient for therapeutic decisions in the elderly.
  • Life expectancy in very old age necessitates a comprehensive health assessment.
  • Health status is influenced by genetics, life-course, and aging processes.

Purpose:

  • To emphasize the importance of multidimensional health evaluation in very old age.
  • To highlight frailty assessment as essential for high-quality geriatric care.
  • To advocate for collaborative care between oncologists and geriatricians for elderly cancer patients.

Summary:

  • Health status in the elderly is a complex interplay of genetic, life-course, and aging factors, leading to frailty.
  • Multidimensional assessment of health, autonomy, and diseases is vital for developing effective care plans.

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Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
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  • Geriatric interventions, though lacking randomized controlled trials in elderly cancer patients, show high potential for improving mortality, morbidity, autonomy, and care quality.

    • Impact:

    • Establishes the need for a shift from chronologic age to functional status in geriatric treatment planning.
    • Underscores the critical role of frailty assessment in optimizing care for elderly individuals.
    • Promotes interdisciplinary collaboration to enhance health outcomes and quality of life for aging populations, particularly in oncology.