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Updated: Jul 4, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

[Lung cancers in the elderly].

Jean Trédaniel¹, Francesco Savinelli, Guillaume Sergent

¹Service d'oncologie médicale, Hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75010 Paris, France. jean.tredaniel@sls.aphp.fr

Bulletin Du Cancer

|December 17, 2008

Summary

Elderly lung cancer patients are under-represented in clinical trials. Age should not limit treatment options; fit elderly patients can benefit from standard therapies, but more research is needed.

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Last Updated: Jul 4, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Area of Science:

Oncology
Geriatric Medicine
Clinical Research

Context:

Lung cancer is the leading cause of cancer-related death globally.
The aging global population leads to an increasing incidence of lung cancer in elderly individuals.
Elderly patients are significantly under-represented in clinical trials for lung cancer treatments.

Purpose:

To highlight the under-representation of elderly lung cancer patients in clinical trials.
To advocate for age-inclusivity in treatment decisions and research.
To outline current therapeutic recommendations for elderly lung cancer patients.

Summary:

Age should not be a barrier to lung cancer treatment; surgical indications remain consistent regardless of age.
Fit elderly patients may benefit from concurrent chemoradiotherapy.
For metastatic disease, single-agent chemotherapy (vinorelbine, gemcitabine, docetaxel) or platinum-based chemotherapy for fit patients are recommended options.
The role of targeted therapies in elderly patients requires further investigation.

Impact:

Emphasizes the need for age-appropriate treatment strategies in lung cancer care.
Calls for the development of dedicated clinical trials for elderly lung cancer patients.
Promotes equitable access to evidence-based treatments for all age groups.