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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...

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Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons·2013
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Pro-nociceptive effects of neuromedin U in rat.

Neuroscience·2003
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Selective depression of nociceptive responses of dorsal horn neurones by SNC 80 in a perfused hindquarter preparation of adult mouse.

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Spinal delta-opioid receptors mediate suppression of systemic SNC80 on excitability of the flexor reflex in normal and inflamed rat.

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Knockdown of spinal metabotropic glutamate receptor 1 (mGluR(1)) alleviates pain and restores opioid efficacy after nerve injury in rats.

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Related Experiment Video

Updated: Jul 4, 2026

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management
09:03

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management

Published on: March 28, 2025

Neuropathic pain: emerging treatments.

A Dray1

  • 1AstraZeneca Research and Development, 7171 Frederick Banting Street, Montreal, Canada. andy.dray@astrazeneca.com

British Journal of Anaesthesia
|May 31, 2008
PubMed
Summary

Neuropathic pain therapies are advancing by targeting ion channels and receptors involved in nerve hyperexcitability. New biological approaches like antibodies offer novel treatments for this challenging neurological disease.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Neurology

Background:

  • Neuropathic pain is a complex neurological disorder with significant unmet therapeutic needs.
  • Understanding overlapping mechanisms and comorbidities is crucial for developing effective interventions.
  • Peripheral and central hyperexcitability are key pathological features.

Purpose of the Study:

  • To review current and emerging therapeutic strategies for neuropathic pain.
  • To highlight molecular targets and biological approaches for intervention.
  • To discuss the potential of novel treatments in clinical validation.

Main Methods:

  • Review of molecular drivers of neuropathic pain, including ion channels and ligand-gated channels.
  • Exploration of therapeutic targets such as CB1 receptors, glutamate receptors, and neuroglial receptors.

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Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
08:16

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Published on: October 6, 2022

Related Experiment Videos

Last Updated: Jul 4, 2026

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management
09:03

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management

Published on: March 28, 2025

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
08:16

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Published on: October 6, 2022

  • Discussion of emerging biological therapies including antibodies, siRNA, and gene therapy.

    • Main Results:

    • Ion channel modulation (Nav1.7, Nav1.8, Nav1.3, Cav2.2, alpha2-delta) shows therapeutic potential.
    • Blocking ligand-gated channels (TRPV1, TRPM8, NNRs) may alleviate neural sensitization.
    • Modulating excitability via CB1 receptors, glutamate receptors, and neuroglial targets offers promising clinical avenues.

    Conclusions:

    • Targeting ion channels, receptors, and neuroglial pathways presents viable therapeutic strategies for neuropathic pain.
    • Emerging biological approaches, including antibodies and gene therapy, represent powerful additions to treatment paradigms.
    • Continued clinical validation is essential for translating these interventions into effective therapies for neuropathic pain.