Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
Several...
Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidence of cervical spine injury in victims of dismounted blast: a systematic review.

BMJ military healthĀ·2024
Same author

Understanding the burden of injury in children from conflict: an analysis of radiological imaging from a Role 3 hospital in Afghanistan in 2011.

BMJ military healthĀ·2023
Same author

Impact of participation in a surgical site infection surveillance network: results from a large international cohort study.

The Journal of hospital infectionĀ·2018
Same author

Experimental platforms to study blast injury.

Journal of the Royal Army Medical CorpsĀ·2018
Same author

Lentiviral gene rescue of a Bernard-Soulier mouse model to study platelet glycoprotein IbĪ² function.

Journal of thrombosis and haemostasis : JTHĀ·2016
Same author

Genetic and acute toxicological evaluation of an algal oil containing eicosapentaenoic acid (EPA) and palmitoleic acid.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research AssociationĀ·2014

Related Experiment Video

Updated: Jul 4, 2026

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
14:26

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

Published on: April 7, 2014

Fluid tolerance while running: effect of repeated trials.

G P Lambert1, J Lang, A Bull

  • 1Department of Exercise Science, Creighton University, Omaha, Nebraska 68178, United States. plambert@creighton.edu

International Journal of Sports Medicine
|May 31, 2008
PubMed
Summary

Repeatedly matching fluid intake to sweat rate during running improves stomach comfort for runners. However, this practice does not alter gastric emptying rates over time.

More Related Videos

Using a Split-belt Treadmill to Evaluate Generalization of Human Locomotor Adaptation
08:04

Using a Split-belt Treadmill to Evaluate Generalization of Human Locomotor Adaptation

Published on: August 23, 2017

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
10:00

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

Related Experiment Videos

Last Updated: Jul 4, 2026

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
14:26

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

Published on: April 7, 2014

Using a Split-belt Treadmill to Evaluate Generalization of Human Locomotor Adaptation
08:04

Using a Split-belt Treadmill to Evaluate Generalization of Human Locomotor Adaptation

Published on: August 23, 2017

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
10:00

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

Area of Science:

  • Exercise Physiology
  • Sports Nutrition

Background:

  • Fluid ingestion during endurance exercise is critical for performance and thermoregulation.
  • Individual tolerance to fluid intake varies, impacting gastrointestinal comfort and absorption.

Purpose of the Study:

  • To assess the impact of repeated sessions of drinking while running on fluid tolerance.
  • To investigate if matching fluid intake to sweat rate improves stomach comfort and affects gastric emptying.

Main Methods:

  • Seven runners performed six 90-minute runs at 65% VO2max.
  • Initial runs involved ad libitum fluid intake; subsequent runs matched fluid intake to measured sweat loss.
  • Stomach comfort, gastrointestinal symptoms, and gastric emptying rate were assessed.

Main Results:

  • Fluid consumption significantly increased in runs matching sweat rate compared to initial runs.
  • Stomach comfort ratings improved progressively over repeated sessions.
  • Gastric emptying rate remained unchanged between early and later sessions.

Conclusions:

  • Repeatedly matching fluid intake to sweat rate enhances fluid tolerance and stomach comfort during running.
  • This strategy does not appear to alter the fundamental rate of gastric emptying.