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Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...

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Related Experiment Video

Updated: Jul 4, 2026

Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis
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Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis

Published on: January 9, 2026

Evidence-based indications for thrombophilia screening.

E Lindhoff-Last1, B Luxembourg

  • 1Department of Internal Medicine, Division of Vascular Medicine/Haemostaseology, University Hospital, Frankfurt/Main, Germany. lindhoff-last@em.uni-frankfurt.de

VASA. Zeitschrift Fur Gefasskrankheiten
|June 3, 2008
PubMed
Summary

Selective thrombophilia screening is cost-effective for individuals with a history of venous thromboembolism. Screening benefits antiphospholipid syndrome patients and selected pregnant individuals, but is not recommended for arterial thrombosis or mass screening in premenopausal women.

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Last Updated: Jul 4, 2026

Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis
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Published on: February 27, 2026

Area of Science:

  • Hematology
  • Reproductive Medicine
  • Clinical Genetics

Background:

  • Thrombophilic defects increase risks for venous thrombosis, fetal loss, and gestational complications.
  • Clinical relevance of thrombophilic defects is growing, necessitating evidence-based screening guidelines.

Purpose of the Study:

  • To review evidence-based indications for thrombophilia screening.
  • To evaluate the clinical utility of thrombophilia screening in various patient populations.

Main Methods:

  • Review of existing literature on thrombophilia screening.
  • Analysis of cost-effectiveness and clinical impact in different scenarios.

Main Results:

  • Selective screening based on personal/family history of venous thromboembolism is more cost-effective than universal screening.
  • Thrombophilia screening results rarely influence anticoagulation duration for acute venous thrombosis, except in antiphospholipid syndrome.
  • Screening is indicated for selected pregnant patients with a history of venous thrombosis or family history.
  • Certain thrombophilias (Factor V Leiden, prothrombin G20210A, anticardiolipin antibodies, protein S deficiency) are associated with pregnancy loss.
  • Oral contraceptives and thrombophilias increase venous thrombosis risk, but mass screening in premenopausal women is not effective.
  • Heritable thrombophilia screening is not useful for arterial thrombosis, except possibly in young patients and children.

Conclusions:

  • Selective thrombophilia screening is recommended based on patient history and specific conditions like antiphospholipid syndrome and pregnancy complications.
  • Further placebo-controlled trials are needed to confirm the therapeutic benefit of antithrombotic drugs in recurrent pregnancy loss with thrombophilia.