Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

An ultrasensitive energy-transfer based photoelectrochemical protein biosensor.

Chemical communications (Cambridge, England)·2016

Same author

Reproducibility and validity of an FFQ developed for adults in Nanjing, China.

The British journal of nutrition·2016

Same author

[Chemical Constituents from Leaves of Hibiscus syriacus and Their α-Glucosidase Inhibitory Activities].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials·2016

Same author

Quantifying Different Tactile Sensations Evoked by Cutaneous Electrical Stimulation Using Electroencephalography Features.

International journal of neural systems·2016

Same author

A Highly Sensitive Immunosorbent Assay Based on Biotinylated Graphene Oxide and the Quartz Crystal Microbalance.

ACS applied materials & interfaces·2016

Same author

Identification of Thyroid Hormones and Functional Characterization of Thyroid Hormone Receptor in the Pacific Oyster Crassostrea gigas Provide Insight into Evolution of the Thyroid Hormone System.

PloS one·2015

Search research articles

Related Experiment Video

Updated: Jul 4, 2026

Sample Preparation in Quartz Crystal Microbalance Measurements of Protein Adsorption and Polymer Mechanics

Sample Preparation in Quartz Crystal Microbalance Measurements of Protein Adsorption and Polymer Mechanics

Published on: January 22, 2020

Quartz crystal microbalance with integrated surface plasmon grating coupler.

Yun Zong¹, Fei Xu, Xiaodi Su

¹Institute of Materials Research and Engineering, Agency for Science, Technology and Research, 3 Research Link, Singapore 117602.

Analytical Chemistry

|June 3, 2008

Summary

This summary is machine-generated.

This study integrates surface plasmon resonance (SPR) with quartz crystal microbalance (QCM) to simplify surface reaction analysis. The new system provides optical and acoustic signals simultaneously, enhancing the study of association and dissociation kinetics.

More Related Videos

Dissipative Microgravimetry to Study the Binding Dynamics of the Phospholipid Binding Protein Annexin A2 to Solid-supported Lipid Bilayers Using a Quartz Resonator

Dissipative Microgravimetry to Study the Binding Dynamics of the Phospholipid Binding Protein Annexin A2 to Solid-supported Lipid Bilayers Using a Quartz Resonator

Published on: November 1, 2018

Epitaxial Nanostructured α-Quartz Films on Silicon: From the Material to New Devices

Epitaxial Nanostructured α-Quartz Films on Silicon: From the Material to New Devices

Published on: October 6, 2020

Related Experiment Videos

Last Updated: Jul 4, 2026

Sample Preparation in Quartz Crystal Microbalance Measurements of Protein Adsorption and Polymer Mechanics

Sample Preparation in Quartz Crystal Microbalance Measurements of Protein Adsorption and Polymer Mechanics

Published on: January 22, 2020

Dissipative Microgravimetry to Study the Binding Dynamics of the Phospholipid Binding Protein Annexin A2 to Solid-supported Lipid Bilayers Using a Quartz Resonator

Dissipative Microgravimetry to Study the Binding Dynamics of the Phospholipid Binding Protein Annexin A2 to Solid-supported Lipid Bilayers Using a Quartz Resonator

Published on: November 1, 2018

Epitaxial Nanostructured α-Quartz Films on Silicon: From the Material to New Devices

Epitaxial Nanostructured α-Quartz Films on Silicon: From the Material to New Devices

Published on: October 6, 2020

Area of Science:

Analytical Chemistry
Surface Science
Spectroscopy

Background:

Quartz crystal microbalance (QCM) is a sensitive acoustic sensor for mass changes.
Surface plasmon resonance (SPR) is an optical technique for detecting binding events.
Combining SPR and QCM offers complementary information but requires complex instrumentation.

Purpose of the Study:

To develop a simplified integrated system combining SPR and QCM.
To enable simultaneous measurement of optical and acoustic signals for surface reactions.
To overcome limitations of conventional combined SPR-QCM instruments.

Main Methods:

Integration of a surface plasmon grating coupler into a QCM device.
Utilizing QCM for simultaneous optical and acoustic signal detection.
Demonstration using a layer-by-layer polyelectrolyte multilayer deposition protocol.

Main Results:

The integrated system simplifies instrumentation by eliminating separate SPR components.
Simultaneous optical and acoustic detection of surface association/dissociation reactions is achieved.
Interference from light reflections is bypassed, improving signal quality.

Conclusions:

The integrated SPR-QCM system offers a simplified and effective approach for studying surface binding kinetics.
This novel configuration retains the full capabilities of conventional combined instruments.
The method is suitable for monitoring adsorption kinetics and multilayer deposition.