Emphasis on cell turnover in two hosts infected by bovine leukemia virus: a rationale for host susceptibility to
Arnaud Florins1, Mathieu Boxus, Fabian Vandermeers
1Gembloux Agricultural University, Cellular and Molecular Biology, Gembloux, Belgium. florins.a@fsagx.ac.be
Abstract:
Bovine leukemia virus (BLV) is a deltaretrovirus that infects and induces accumulation of B-lymphocytes in the peripheral blood and lymphoid tissues of cattle, leading to leukemia/lymphoma. BLV can also be experimentally transmitted to sheep, in which disease appears earlier and at higher frequencies. Abnormal accumulation of leukemic B-lymphocytes results from an alteration of different parameters that include cell proliferation and death as well as migration to lymphoid tissues. Interestingly, B lymphocyte turnover is increased in BLV-infected sheep but reduced in cattle, revealing a potential relationship between cell kinetics and disease progression.
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