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Are we there yet? Tracking the development of new model systems
Arhat Abzhanov1, Cassandra G Extavour, Andrew Groover
1Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Trends in Genetics : TIG
|June 3, 2008
Summary
New genetic model systems are crucial for understanding organismal diversity. Advances in DNA sequencing and reverse genetics are making it easier to develop and utilize these powerful research tools for biological discovery.
Area of Science:
- Genetics
- Developmental Biology
- Evolutionary Biology
Background:
- Understanding the genetic and developmental basis of organismal diversity requires new model systems.
- Historically, developing model systems demanded significant investment.
- Recent technological advancements are lowering barriers to model system development.
Purpose of the Study:
- To review the types of research questions addressable by new genetic model systems.
- To outline essential characteristics and molecular tools for developing novel model systems based on research focus.
- To encourage exploration and development of emerging and favorite model organisms.
Main Methods:
- Literature review of emerging genetic model systems.
- Analysis of research questions advanced by these models.
- Evaluation of characteristics and molecular tools for new model systems.
Main Results:
- New model systems are enabling novel research into organismal diversity.
- Decreasing DNA sequencing costs and advances in reverse genetics facilitate model system development.
- The choice of model system and tools depends on specific research objectives.
Conclusions:
- Emerging genetic model systems are vital for advancing biological research.
- Technological progress is democratizing the development of new model systems.
- Researchers are encouraged to adopt and develop molecular tools for diverse organisms.
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