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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

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Published on: February 16, 2018

A potentiometric protein sensor built with surface molecular imprinting method.

Yantian Wang¹, Yanxiu Zhou, Jonathon Sokolov

¹Department of Materials Science and Engineering, Stony Brook University, Stony Brook, NY 11794-2275, USA.

Biosensors & Bioelectronics

|June 3, 2008

Summary

This study presents a novel potentiometric protein sensor using surface molecular imprinting. The developed sensor selectively detects myoglobin and hemoglobin, offering a promising tool for protein analysis.

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Real Time Measurements of Membrane Protein:Receptor Interactions Using Surface Plasmon Resonance (SPR)

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Published on: November 29, 2014

Area of Science:

Electrochemistry
Materials Science
Biomedical Engineering

Background:

Surface molecular imprinting offers advantages over bulk polymers, including improved site accessibility and faster response times.
Developing selective and sensitive protein sensors is crucial for diagnostics and research.

Purpose of the Study:

To develop a potentiometric protein sensor utilizing surface molecular imprinting.
To demonstrate the selective detection of target proteins using the developed sensor.

Main Methods:

Fabrication of a sensing layer on a gold-coated silicon chip using self-assembled monolayers of alkanethiol.
Utilizing target protein molecules as templates for the imprinting process.
Employing potentiometric measurements for protein detection.

Main Results:

The developed sensor demonstrated selective detection of myoglobin and hemoglobin.
The sensor maintained selectivity even in the presence of other proteins in the solution.
Surface molecular imprinting facilitated efficient re-occupation of recognition sites.

Conclusions:

A novel potentiometric protein sensor based on surface molecular imprinting was successfully developed.
The sensor exhibits high selectivity for myoglobin and hemoglobin detection.
This technique offers a robust platform for developing electrochemical biosensors.