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Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

Variables associated with contrast-enhanced cardiovascular magnetic resonance in hypertrophic cardiomyopathy:

Eduardo Payá1, Francisco Marín, Josefa González

  • 1Department of Cardiology, Hospital General Universitario, Alicante, Spain.

Journal of Cardiac Failure
|June 3, 2008
PubMed

Insights

Late gadolinium enhancement (LGE) is common in hypertrophic cardiomyopathy (HCM) and linked to increased wall thickness and ventricular tachycardia. LGE also correlates with more sudden cardiac death risk factors in HCM patients.

Area of Science:

  • Cardiology
  • Medical Imaging

Background:

  • Hypertrophic cardiomyopathy (HCM) is characterized by increased myocardial collagen and disarray.
  • Late gadolinium enhancement (LGE) in cardiovascular magnetic resonance (CMR) visualizes myocardial scarring, often in HCM.
  • LGE extent in HCM is linked to increased risk factors for sudden cardiac death.

Purpose of the Study:

  • To characterize clinical features and sudden death risk factors in HCM patients.
  • To investigate the relationship between LGE on CMR and these clinical factors.

Main Methods:

  • 120 HCM patients underwent clinical evaluation and CMR with LGE assessment.
  • Risk factors for sudden death, exercise capacity, and NT-proBNP levels were analyzed.
  • Multivariate analysis identified predictors of LGE.

Main Results:

  • 69% of patients showed LGE.
  • LGE patients had greater left ventricular wall thickness, more frequent obstruction, and nonsustained ventricular tachycardia.
  • LGE was associated with worse exercise capacity, higher NT-proBNP, and a greater number of sudden death risk factors.

Conclusions:

  • Late gadolinium enhancement is a frequent finding in hypertrophic cardiomyopathy.
  • Increased maximal left ventricular wall thickness and nonsustained ventricular tachycardia are associated with LGE.
  • LGE in HCM correlates with elevated risk factors for sudden death and impaired functional status.
Abstract

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