Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Changes in the cortical GABAergic inhibitory system in a Spinal Muscular Atrophy mouse model.

Cell death & disease·2026
Same author

Mitochondrial energetic failure underlies FLVCR1-related sensory neuropathy.

Communications biology·2026
Same author

From Ornamental Value to Antioxidant Activity: Comparative Phytochemistry of <i>Lavandula</i> Species and Cultivars.

Metabolites·2026
Same author

Valorisation of mediterranean basin fruit by-products: bioactive composition, applications, and future research directions.

Natural product research·2025
Same author

Editorial: Methods in cellular neurobiology research.

Frontiers in cellular neuroscience·2025
Same author

Cultivar-specific responses of young olive trees to water deficit: impacts on physiology, leaf anatomy, and fruit quality in 'Arbequina', 'Leccio del Corno' and 'Maurino'.

Plant physiology and biochemistry : PPB·2025
Same journal

Deletion of Fbxo25 causes excessive repetitive behavior, impaired recognition memory, reduced dendritic complexity, and aberrant protein expression in mice.

Progress in neurobiology·2026
Same journal

Neuropsychiatric Disease Mechanisms and Interventions. from 22q11.2 Deletion Syndrome Experimental Studies.

Progress in neurobiology·2026
Same journal

REM sleep as a dummy-model of the world: A theoretical framework.

Progress in neurobiology·2026
Same journal

CA3 transiently modulates spatial representation in CA1.

Progress in neurobiology·2026
Same journal

Love, death, and oxytocin: In memory of Larry Young.

Progress in neurobiology·2026
Same journal

Assessing peripheral oxytocin and cortisol levels and epigenetic variations of oxytocin receptor and glucocorticoid receptor genes in school-aged preterm-born children.

Progress in neurobiology·2026
See all related articles

Related Experiment Video

Updated: Jul 4, 2026

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
07:09

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

BDNF as a pain modulator.

Adalberto Merighi1, Chiara Salio, Alessia Ghirri

  • 1Dipartimento di Morfofisiologia Veterinaria, University of Turin, Turin, Italy. adalberto.merighi@unito.it

Progress in Neurobiology
|June 3, 2008
PubMed
Summary
This summary is machine-generated.

Brain-Derived Neurotrophic Factor (BDNF) modulates synaptic transmission in pain pathways. This neurotrophin influences fast and slow signaling in the spinal cord, particularly within synaptic glomeruli.

More Related Videos

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management
09:03

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management

Published on: March 28, 2025

Related Experiment Videos

Last Updated: Jul 4, 2026

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
07:09

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management
09:03

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management

Published on: March 28, 2025

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pain Research

Background:

  • Neurotrophins, including BDNF, are implicated in synaptic plasticity and neuronal function.
  • BDNF plays a role in pain signaling at both spinal and supraspinal levels.
  • The distribution and function of the BDNF receptor, trkB, are relevant to its actions.

Purpose of the Study:

  • To investigate the role of BDNF in modulating synaptic transmission within pain pathways.
  • To characterize the neuronal mechanisms underlying BDNF's effects on synaptic efficiency.
  • To identify key anatomical sites involved in BDNF-mediated synaptic modulation in the spinal cord.

Main Methods:

  • Anatomical and physiological characterization of BDNF synthesis, storage, and release.
  • Histological analysis of trkB receptor distribution.
  • Functional studies using acute slices and intact animal models.
  • Investigation of BDNF's effects on glutamatergic, GABAergic, glycinergic, and peptidergic neurotransmission.

Main Results:

  • BDNF modulates fast excitatory (glutamatergic) and inhibitory (GABAergic/glycinergic) neurotransmission.
  • BDNF also influences slow peptidergic neurotransmission in the spinal cord.
  • Synaptic glomeruli in lamina II are identified as critical sites for BDNF's modulatory actions.

Conclusions:

  • BDNF is a significant modulator of synaptic transmission in spinal pain pathways.
  • BDNF influences both fast and slow synaptic signaling, impacting pain processing.
  • Synaptic glomeruli in lamina II are key neuroanatomical substrates for BDNF's effects on pain signaling.