Related Experiment Video

Updated: Jul 4, 2026

Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins
05:35

Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins

Published on: March 3, 2016

Cohesin protein SMC1 is a centrosomal protein

Jikui Guan1, Emelie Ekwurtzel, Ulrik Kvist

  • 1Department of Cell and Molecular Biology, Karolinska Institute, Berzelius väg 35, SE-171 77 Stockholm, Sweden.

Biochemical and Biophysical Research Communications
|June 3, 2008
PubMed

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Cohesins02:20

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Cohesins02:20

Cohesins

Cohesin protein complexes are a molecular glue that holds two sister chromatids together. They play an important role both in mitosis and meiosis. In mitosis, all cohesin complexes present on the chromosomes are removed before the start of the anaphase stage.
Cohesin complexes in Meiotic Division
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Separation of Sister Chromatids02:17

Separation of Sister Chromatids

At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
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Separation of Sister Chromatids02:17

Separation of Sister Chromatids

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At the onset of anaphase, separase, a proteolytic enzyme, is...
Condensins02:15

Condensins

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Condensins02:15

Condensins

Condensins are large protein complexes that use ATP to fuel the assembly of chromosomes during mitosis. They transform the tangled, shapeless mass of post-interphase DNA into individualized chromosomes by compacting, organizing, and segregating chromosomal DNA.
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