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Updated: Jul 4, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
Published on: February 21, 2018
Multiple ways of C/EBPalpha inhibition in myeloid leukaemia
1Drug Target Discovery and Development Division, Central Drug Research Institute (CDRI), Lucknow 226001, India. arun3vedi@cdri.res.in
Abstract:
Transcription factors play a crucial role in myeloid differentiation and lineage determination. Tumour suppressor protein C/EBPalpha is a key regulator of granulocytic differentiation whose functional inactivation has become a pathophysiological signature of myeloid leukaemia. In this review we describe various mechanisms such as antagonistic protein-protein interaction, mutation and posttranslational modifications of C/EBPalpha which lead to its transcriptional inhibition and render C/EBPalpha inactive in its functions.
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