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Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
Published on: August 15, 2025
Surgery for temporal lobe epilepsy after cerebral malaria
O E M G Schijns1, V Visser-Vandewalle, E M P Lemmens
1Department of Neurosurgery, University Hospital Maastricht, Maastricht, The Netherlands. oschijns@yahoo.com
Seizure
|June 3, 2008
Summary
This study reports a rare case of mesial temporal lobe epilepsy (MTLE) following cerebral malaria, successfully treated with surgery. The findings suggest a potential link between cerebral malaria and mesial temporal sclerosis (MTS).
Area of Science:
- Neurology
- Infectious Diseases
- Neurosurgery
Background:
- Temporal lobe epilepsy (TLE) is a common indication for epilepsy surgery.
- Mesial temporal lobe epilepsy (MTLE) is often caused by mesial temporal sclerosis (MTS).
- Cerebral malaria is a severe complication of Plasmodium falciparum infection.
Purpose of the Study:
- To report the first case of MTLE onset after cerebral malaria.
- To investigate the potential pathophysiological link between cerebral malaria and MTS.
- To evaluate the surgical outcome in a patient with MTLE secondary to cerebral malaria.
Main Methods:
- Case report of a 50-year-old male patient.
- Diagnosis of MTLE with MTS confirmed by MRI.
- Surgical treatment: anteromedial temporal lobe resection with amygdalohippocampectomy.
Main Results:
- The patient developed MTLE subsequent to cerebral malaria.
- MRI confirmed MTS as the underlying pathology.
- The patient achieved seizure freedom 36 months post-surgery.
Conclusions:
- This case highlights a potential novel etiology for MTLE.
- Cerebral malaria may contribute to the development of MTS.
- Surgical intervention can be effective for MTLE secondary to cerebral malaria.
