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The half-life of a reaction (t1/2) is the time required for one-half of a given amount of reactant to be consumed. In each succeeding half-life, half of the remaining concentration of the reactant is consumed. For example, during the decomposition of hydrogen peroxide, during the first half-life (from 0.00 hours to 6.00 hours), the concentration of H2O2 decreases from 1.000 M to 0.500 M. During the second half-life (from 6.00 hours to 12.00 hours), the concentration decreases from 0.500 M to...
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Related Experiment Video

Updated: Jul 4, 2026

Blast Quantification Using Hopkinson Pressure Bars
09:41

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Published on: July 5, 2016

Calculation of pressure half-time.

Mark A Oyama1, Jess A Weidman, Steven G Cole

  • 1Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, PA 19104, USA. maoyama@vet.upenn.edu

Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology
|June 3, 2008
PubMed
Summary

Doppler echocardiography effectively measures mitral valve stenosis severity using pressure half-time (PHT). This method accurately assesses obstruction before and after balloon valvuloplasty in dogs.

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Area of Science:

  • Cardiology
  • Veterinary Medicine
  • Diagnostic Imaging

Background:

  • Obstructive cardiac lesions, like mitral valve stenosis, require accurate assessment of severity.
  • Doppler echocardiography is a key non-invasive imaging technique in cardiovascular diagnostics.
  • Pressure half-time (PHT) is a crucial Doppler-derived parameter for evaluating stenosis severity.

Observation:

  • This study details the methodology for measuring PHT in a canine model.
  • Measurements were taken in a dog diagnosed with mitral valve stenosis.
  • PHT was assessed both before and after therapeutic intervention (balloon valvuloplasty).

Findings:

  • The study demonstrates the practical application of Doppler echocardiography for PHT measurement.
  • The methodology allows for quantitative assessment of mitral valve stenosis.
  • Changes in PHT correlate with the success of balloon valvuloplasty in reducing obstruction.

Implications:

  • Accurate PHT measurement aids in clinical decision-making for valvular heart disease.
  • This technique can improve the management and prognosis of obstructive cardiac lesions.
  • The findings support the utility of Doppler echocardiography in veterinary cardiology practice.