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Published on: January 31, 2022
N-phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats
Julija Matijević-Sosa1, Ita Samarzija, Lorena Honović
1Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia. jmatijevic@pharma.hr
Abstract:
The aim of this study was to investigate the activity of N-phthaloyl-glycine-hydroxamic acid (Phth-Gly-HA) as a new iron chelator in vivo to be used in iron overload diseases. After intraperitoneal application of Phth-Gly-HA to male rats (1 mg kg(-1) body mass) once a day for seven days, iron serum level decreased by 21%, whereas the iron value dropped by 32% in female rats (1.5 mg kg(-1) body mass). The results indicate that the tested substance has the ability to bind serum iron by complexation. Besides transferrin iron release, mobilization of ferritin iron is also possible.
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