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Executive dysfunction in elderly bipolar manic patients.

Faith M Gunning-Dixon1, Christopher F Murphy, George S Alexopoulos

  • 1Weill Cornell Institute of Geriatric Psychiatry, Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA. fgd2002@med.cornell.edu

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
|June 3, 2008
PubMed
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Elderly bipolar manic patients show significant executive function deficits, performing worse than depressed patients and healthy controls. These findings highlight frontostriatal network abnormalities in late-life bipolar disorder.

Area of Science:

  • Geriatric Psychiatry
  • Neuropsychology
  • Neuroscience

Background:

  • Frontostriatal networks are crucial for executive functions.
  • Executive dysfunction is a known feature of bipolar disorder.
  • Little is known about executive functioning in elderly bipolar patients.

Purpose of the Study:

  • To examine executive functioning in elderly bipolar patients using neuropsychological measures.
  • To investigate the functioning of frontostriatal networks in this population.
  • To compare executive skills in manic elderly patients with depressed elderly patients and healthy controls.

Main Methods:

  • Neuropsychological assessment of executive skills.
  • Inclusion of 14 elderly bipolar I manic patients, 14 elderly unipolar major depression patients, and 14 nonpsychiatric comparison subjects.

Related Experiment Videos

  • Use of Dementia Rating Scale (initiation/perseveration) and Go/No-Go tasks.

    • Main Results:

    • Elderly bipolar manic patients exhibited significant deficits in initiation/perseveration and response inhibition.
    • Manic patients performed significantly worse than both depressed patients and nonpsychiatric comparison subjects.
    • No correlation was found between manic symptom severity and executive performance in this sample.

    Conclusions:

    • Elderly bipolar manic patients demonstrate executive functioning deficits compared to nonpsychiatric samples.
    • These deficits can be more severe in manic elders than in unipolar depressed elders.
    • Findings support further investigation into frontostriatal network abnormalities in late-life bipolar disorder.