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Related Experiment Videos

[Tumor markers--a diagnostic and prognostic test].

G S Moroz, V I Dryzhak, I N Dykan

    Voprosy Onkologii
    |January 1, 1991
    PubMed
    Summary

    Carcinoembryonic antigen (CEA) is a reliable blood marker for lung and colon cancer detection. Its levels indicate tumor presence, normalize after surgery, and rise with recurrence, aiding in cancer monitoring.

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    [Fibronectin in cancerous diseases].

    Likars'ka sprava·1997

    Area of Science:

    • Oncology
    • Biochemistry
    • Medical Diagnostics

    Background:

    • Biomarkers play a crucial role in cancer diagnosis and monitoring.
    • Accurate detection of lung, hepatopancreatoduodenal, and colonic cancers is essential for effective treatment.
    • Tumor-associated antigens can serve as indicators of malignancy.

    Purpose of the Study:

    • To evaluate the efficacy of various blood markers, including carcinoembryonic antigen (CEA), in diagnosing and monitoring lung, hepatopancreatoduodenal, and colonic cancers.
    • To compare the diagnostic value of CEA with other markers like alpha-fetoprotein, ferritin, cortisol, ACTH, triiodothyronine, and thyroxin.
    • To assess the utility of CEA in reflecting treatment response and disease recurrence in colorectal cancer patients.

    Main Methods:

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  • Radioimmunoassay was used to measure blood levels of CEA, alpha-fetoprotein, ferritin, ACTH, triiodothyronine, and thyroxin.
  • The study included 217 cancer patients (lung, hepatopancreatoduodenal, colonic), 61 patients with non-tumor pathology, and 37 healthy controls.
  • CEA levels were analyzed in relation to cancer diagnosis, surgical intervention, and disease recurrence.

    • Main Results:

    • Carcinoembryonic antigen (CEA) demonstrated the highest reliability as a marker for lung and colonic cancer, and for tumor-related mechanical jaundice.
    • In 65-100% of cancer patients, CEA concentrations exceeded those found in healthy controls.
    • CEA levels normalized post-radical surgery for colorectal cancer and elevated again with recurrence or distant metastases, indicating its utility in monitoring disease status.
    • Ferritin, cortisol, and ACTH were found to be less efficient markers compared to CEA.

    Conclusions:

    • Carcinoembryonic antigen (CEA) is a valuable and reliable biomarker for the detection and monitoring of lung and colonic cancers.
    • CEA's dynamic changes in response to treatment and recurrence make it a useful tool for clinical management of colorectal cancer.
    • While other tested markers showed lower efficiency, CEA's performance supports its routine use in the diagnostic workup and follow-up of these malignancies.