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Related Experiment Video

Updated: Jul 4, 2026

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity

Published on: December 14, 2016

Basophils enhance immunological memory responses.

Andrea Denzel¹, Ulrich A Maus, Manuel Rodriguez Gomez

¹Department of Internal Medicine II, University Hospital Regensburg, 93042 Regensburg, Germany.

Nature Immunology

|June 3, 2008

Summary

Basophils are key to immunological memory, producing crucial interleukins and antibodies. Their depletion impairs humoral memory and increases sepsis susceptibility, highlighting their vital role in immune responses.

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Published on: July 11, 2015

Area of Science:

Immunology
Cellular Biology
Infectious Disease

Background:

The cellular mechanisms underlying immunological memory are not fully understood.
Basophils, a type of white blood cell, have been historically underappreciated in adaptive immunity.

Purpose of the Study:

To investigate the role of basophils in establishing and maintaining humoral immunological memory.
To determine the contribution of basophils to antibody production and immune cell interactions during secondary immune responses.

Main Methods:

Mice were immunized and restimulated with antigens.
Basophil depletion was induced using specific antibodies.
Antigen-reactive basophils were adoptively transferred.
Humoral responses, including antibody production and B cell proliferation, were quantified.
Cytokine levels (interleukins 6 and 4) were measured.

Main Results:

Basophils bound intact antigens and were primary sources of interleukins 6 and 4 upon antigen restimulation.
Depletion of basophils significantly reduced humoral memory and increased susceptibility to Streptococcus pneumoniae sepsis.
Adoptive transfer of basophils enhanced specific antibody production and, with CD4(+) T cells, boosted B cell proliferation and immunoglobulin production.

Conclusions:

Basophils are critical cellular components of humoral immunological memory.
Basophil-derived interleukins 6 and 4 are essential for enhancing T cell help to B cells.
Basophils play a significant role in protective adaptive immunity against bacterial infections.