The angiogenesis in colorectal carcinomas with and without lymph node metastases
Simona Gurzu1, J Jung, L Azamfirei
1Department of Pathology, University of Medicine and Pharmacy, Targu Mures, Romania. simonagurzu@yahoo.com
Summary
Microvascular density (MVD) in colorectal cancer (CRC) varies by lymph node status and colon location. Angiogenesis intensity fluctuates, suggesting personalized anti-angiogenic treatment is crucial for metastatic CRC patients.
Area of Science:
- Oncology
- Pathology
Background:
- Anti-angiogenic therapy improves prognosis in metastatic colorectal carcinoma (CRC) when combined with chemotherapy.
- Microvascular density (MVD) is a key indicator of tumor angiogenesis.
Purpose of the Study:
- To investigate the correlation between MVD and lymph node status in CRC.
- To compare angiogenesis intensity between right and left colon segments in CRC patients.
Main Methods:
- Studied 187 colorectal cancer (CRC) cases.
- Assessed microvascular density (MVD) using CD31 and CD105 markers.
- Correlated MVD with lymph node metastasis status (pN0, pN1, pN2) and tumor location (right vs. left colon).
Main Results:
- In the right colon, higher MVD was observed in pN0 and pN2 stages.
- In the rectum and sigmoid colon, peak angiogenesis intensity occurred in pN0 and pN1 stages, decreasing in pN2.
- No significant MVD differences were found in the descending colon based on lymph node status.
Conclusions:
- Specific lymph node stages (pN0/pN1 in rectum/sigmoid, pN0/pN2 in right colon) may benefit most from anti-angiogenic therapy.
- Angiogenesis intensity in CRC exhibits an oscillating pattern, not a simple increase.
- Angiogenesis is an independent prognostic factor, necessitating individualized anti-angiogenic treatment strategies.
