Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Radium-223 in the Treatment of Metastatic Castrate-Resistant Prostate Cancer.

Irish medical journal·2022

Same author

Investigating a clinically actionable <i>BRAF</i> mutation for monitoring low-grade serous ovarian cancer: A case report.

Case reports in women's health·2022

Same author

Immune Checkpoint Inhibitors and Palliative Care at the End of Life: An Irish Multicentre Retrospective Study.

Journal of palliative care·2022

Same author

Osteosarcoma and second malignant neoplasms: a case series.

Irish journal of medical science·2019

Same author

A Survey of Colorectal Cancer Surveillance Practices In Ireland, And Implementation of A Survivorship Care Plan Pilot Programme

Irish medical journal·2019

Same author

Post-Chemotherapy Retroperitoneal Lymph Node Dissection in Patients with Non-Seminomatous Germ Cell Tumour (NSGCT).

Irish medical journal·2018

Search research articles

Related Experiment Videos

Primary bone lymphoma: single institution case series.

D G Power¹, G P McVey, G Korpanty

¹Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St, Dublin 7, Ireland. drdgpower@gmail.com

Irish Journal of Medical Science

|June 3, 2008

Summary

This summary is machine-generated.

Primary bone lymphoma (PBL) treatment outcomes are promising, with a 100% survival rate observed in a 20-year study. Combined chemotherapy and radiotherapy is the preferred approach for this rare bone cancer.

Related Experiment Videos

Area of Science:

Oncology
Hematology
Orthopedic Oncology

Background:

Primary bone lymphoma (PBL) is a rare malignancy, comprising <2% of adult lymphomas and 3% of primary bone cancers.
The rarity of PBL limits prospective trials, creating uncertainty regarding optimal treatment strategies.

Purpose of the Study:

To report on a 20-year experience in treating patients diagnosed with primary bone lymphoma.
To evaluate treatment modalities and long-term outcomes for PBL.

Main Methods:

A retrospective analysis of patients diagnosed with PBL was conducted using a hospital database.
Data collected included patient demographics, treatment regimens, and long-term follow-up information.

Main Results:

Twelve patients with PBL were identified between January 1989 and July 2007.
Long extremity bones were the most frequent sites of presentation; three patients had multifocal disease.
Overall survival was 100% with a median follow-up of 8 years, with treatments including surgery, chemotherapy, and radiotherapy.

Conclusions:

Combined modality therapy, specifically chemotherapy followed by radiotherapy, is recommended as the primary treatment for PBL.
Exceptions to this approach include cases with presenting neurological compromise or pathological fractures.