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The impact of inherited thrombophilia on surgery: a factor to consider before transplantation?

Elias Kfoury1, Ali Taher, Said Saghieh

  • 1Department of Surgery, American University of Beirut Medical School, Beirut, Lebanon.

Molecular Biology Reports
|June 3, 2008
PubMed

Insights

This review discusses inherited thrombophilia and hypercoagulability in various surgeries. It highlights complications and the importance of pre-operative screening for thrombosis risk.

Area of Science:

  • Medical Science
  • Hematology
  • Surgical Science

Background:

  • Hypercoagulability, particularly inherited thrombophilia, presents risks in surgical patients.
  • Understanding these risks is crucial for preventing post-operative complications.

Purpose of the Study:

  • To review inherited thrombophilia in major surgical procedures.
  • To discuss associated complications and the role of pre-operative screening.

Main Methods:

  • Literature search of Medline and cross-referenced articles.
  • Focused on thrombophilia, screening, and surgical complications.

Main Results:

  • Discusses genetic mutations (Factor V Leiden, Prothrombin, MTHFR) and deficiencies (Protein C, S) predisposing to thrombosis.
  • Details common and uncommon complications of thrombophilia in kidney, pancreas, orthopedic, vascular, and cardiac surgeries.

Conclusions:

  • Pre-operative screening for thrombophilia is increasingly important for surgeons and internists.
  • Evidence-based review updates current understanding of thrombophilia in surgical contexts.

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