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Related Experiment Video

Updated: Jul 4, 2026

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

[Molecular markers are associated with early computed tomography ischemic changes].

M Rodríguez-Yáñez¹, M Castellanos, T Sobrino

¹Servicio Neurología, Laboratorio de Investigación de Neurociencias Clínicas, Hospital Clínico Universitario, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.

Neurologia (Barcelona, Spain)

|June 3, 2008

Summary

Molecular markers like glutamate, IL-6, and MMP-9 are linked to early stroke signs on CT scans. Elevated levels of these markers indicate a worse prognosis in acute ischemic stroke patients.

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A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

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Published on: September 16, 2017

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Last Updated: Jul 4, 2026

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

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Published on: September 25, 2019

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Published on: September 16, 2017

Area of Science:

Neuroscience
Biomarkers
Stroke Research

Background:

Acute ischemic stroke involves complex mechanisms including neurotoxicity, neuroinflammation, and blood-brain barrier (BBB) disruption.
Cranial computed tomography (CT) is crucial for acute stroke diagnosis and patient selection for treatments.
Identifying early molecular markers associated with CT findings can improve stroke management.

Purpose of the Study:

To identify molecular markers of neuroexcitotoxicity, neuroinflammation, and BBB disruption in acute stroke.
To correlate these molecular markers with early ischemic changes on CT scans, specifically the Alberta Stroke Program Early CT Score (ASPECTS).

Main Methods:

Prospective study of 311 ischemic stroke patients within 24 hours of symptom onset.
Categorization into three groups based on time to hospital arrival: ≤6h, 6-12h, and >12h.
Measurement of glutamate, interleukin-6 (IL-6), and matrix metalloproteinase-9 (MMP-9) levels, correlated with ASPECTS scores from cranial CT.

Main Results:

Lower ASPECTS scores (≤7) were associated with worse prognosis.
Elevated glutamate, IL-6, and MMP-9 levels were significantly associated with ASPECTS scores ≤7.
Logistic regression revealed glutamate (≤6h), IL-6 (6-12h), and MMP-9 (>12h) were independently linked to ASPECTS ≤7.

Conclusions:

The ASPECTS score serves as a surrogate for early neurological deterioration and infarct volume in acute stroke.
Molecular markers of neuroexcitotoxicity, neuroinflammation, and BBB disruption are associated with early CT signs of ischemia.
These findings highlight potential biomarkers for assessing stroke severity and prognosis early on.